In the 50-plus years since the discovery of nude mice, the field has changed significantly due to the development of gene-targeting technology. This is a particular mouse strain that has a mostly “hairless” phenotype (Pantelouris 1968 Mecklenburg L et al., 2004). It was in the 1960s that the first publication specifically mentioned nude mice, also known as athymic mice. Their relatively small size, and both genetic and physiological similarity to humans, make mice a model organism for human disease. Fogh, J Giovanella, B.C.The mouse is arguably the most widely used mammalian model in biomedical research.
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